The Medicinal Chemists Notebook

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CYPs are mighty synthesis machines

CYPs are mighty synthesis machines This is an insightful article by a group at University of Dundee[…]

That will never be a drug!

“That will never be a drug!” How tempting it is to say that, because it’s almost always[…]

GIGO = garbage in, gold out?

GIGO = garbage in, gold out? In an effort by a team at AstraZeneca, novel PROTAC degraders[…]

Potent macrocycles, served as you like them…de novo

If there is one area that would benefit tremendously from de novo design tools, it is in[…]

Big things come in little packages

Big things come in little packages A recent article by a team in Genentech highlighted a RIPK1[…]

What does a mummy smell like?  It’s all about the chemistry…

What does a mummy smell like?  It’s all about the chemistry… I can honestly say that is[…]

Chemists love chiral molecules, until they don’t..

Chemists love chiral molecules, until they don’t… This paper by Peter O’Brien at University of York, and[…]

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